0142 The Cumulative Effect of Partial Chronic Sleep Restriction on the Neural Processing Stream in Neurologically Normal Individuals

Introduction Event-related potentials (ERP) are averaged electroencephalogram (EEG) responses to stimuli enabling precise temporal characterization of neural processing. We analyzed the temporal evolution and course of cognitive processing impairments during a 16 day randomized, cross-over sleep restriction experiment, by analyzing visual attention (N2pc), stimulus classification (P3), and decision making (error-related negativity (ERN) and positivity (Pe)) ERPs. Methods Eighteen healthy subjects (8 women, 10 men; age 22.8±4.88, range 18-36 years underwent sleep restriction (3 acclimation nights of 9 hours of time in bed, then 9 experimental 4 hours nights, then 3 recovery sleep nights), and control sleep (15 nights at 9 hours of time in bed) sequences in random order. EEG recordings during a visual attention task were completed once (day 3) during the acclimation period, 3 times during the experimental period (days 5, 6, 9), and once in the recovery period (day 15). Post-hoc off-line ERP data processing yielded N2pc, P3, and ERN/Pe waveforms with comparison of primary amplitude and latency measures across experimental timepoints utilizing mixed linear regression modeling. Results ERN and Pe amplitudes were significantly reduced during sleep restricted days 6 and 9 (both p