ANTI-PROLIFERATIVE ACTIVITIES OF 32 MALAYSIAN PLANT SPECIES IN BREAST CANCER CELL LINES

Anti-proliferative activities of 143 crude extracts obtained from 32 plants collected from the rain forests of Pahang, Malaysia, were evaluated in two breast cancer cell lines, i.e. MCF-7 and T47D, obtained from the American Type Culture Collection, USA. The objective of this study was to bioprospect a list of plants to find out their potential to be developed into anti-cancer drug(s), by means of bioassay guided isolation procedure. After performing sulforhodamine-B assay, 13 crude extracts from 11 plant species were found to have active anti-proliferative effects (IC50 ≤ 100 μg ml-1). Aktiviti anti-proliferasi 143 ekstrak mentah daripada 32 tumbuhan yang diperoleh daripada hutan hujan Pahang, Malaysia dikaji terhadap dua jenis sel kanser buah dada iaitu MCF-7 dan T47D yang diperoleh daripada Koleksi Kultur Tip Amerika, Amerika Syarikat. Kajian ini menjalankan bioprospek terhadap tumbuhan bagi menilai potensi mereka untuk dibangunkan menjadi ubat anti-kanser menggunakan kaedah pengasingan biocerakinan. Selepas cerakinan sulforhodamina-B, 13 ekstrak mentah daripada 11 spesies tumbuhan dikenal pasti mempunyai kesan anti-proliferasi yang aktif (IC50 ≤ 100 μg ml-1).