Synthesis, Structure, and Biological Activity of 4-R-4-Oxo-2-[2-(phenylamino)benzoyl]hydrazinylidene-N-hetarylbutanamides

Synthesis, Structure, and Biological Activity of 4-R-4-Oxo-2-[2-(phenylamino)benzoyl]hydrazinylidene-N-hetarylbutanamides

Decyclization of N ′-[5-R-2-oxofuran-3(2 H )-ylidene]-2-(phenylamino)benzohydrazides under the action of heterocyclic amines leads to the formation of N -hetaryl-4-R-4-oxo-2-[2-(phenylamino)benzoyl]hydrazinylidenebutanamides. Antinociceptive and anti-inflammatory activity of the obtained compounds w...

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Veröffentlicht in:Russian journal of general chemistry 2019-12, Vol.89 (12), p.2345-2352
Hauptverfasser: Kizimova, I. A., Igidov, N. M., Dmitriev, M. V., Chashchina, S. V., Makhmudov, R. R., Siutkina, A. I.
Format: Artikel
Sprache:eng
Schlagworte:
Amines
Biological activity
Chemical tests and reagents
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Furans
Heterocyclic amines
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Zusammenfassung:Decyclization of N ′-[5-R-2-oxofuran-3(2 H )-ylidene]-2-(phenylamino)benzohydrazides under the action of heterocyclic amines leads to the formation of N -hetaryl-4-R-4-oxo-2-[2-(phenylamino)benzoyl]hydrazinylidenebutanamides. Antinociceptive and anti-inflammatory activity of the obtained compounds was studied.
ISSN:1070-3632
1608-3350
DOI:10.1134/S107036321912003X