Towards a GDPR compliant way to secure European cross border Healthcare Industry 4.0

•A reference architectural model industry 4.0 for the healthcare sector.•GDPR implications.•A set of tools for dealing with consent management and data hiding tools in a cross border situation.•A case study illustrating the use of the reference architectural model. The Health sector is gaining momentum within the Industry 4.0. National Health Systems are tightly connected to different complex systems, and a wide set of devices. NHSs are processing and managing patients’ data, and they are exchanging sensitive information cross different countries. This paper takes into account legal aspects such as GDPR and it extends the Healthcare Industry architecture reference model, with a set of tools dealing with consent management and data hiding tools A case study illustrates the use of the reference architectural model.