Hepatosplenic T‐cell lymphoma following infliximab therapy for Crohn's disease

Tumour necrosis factor inhibitors have revolutionised the management of Crohn's disease, but reports of a possible association between concomitant infliximab and immunomodulator therapy and hepatosplenic T-cell lymphoma (a rare form of aggressive non-Hodgkin's lymphoma) have emerged. We de...

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Veröffentlicht in:	Medical journal of Australia 2008-10, Vol.189 (8), p.464-465
Hauptverfasser:	Drini, Musa, Prichard, Peter J, Brown, Gregor J E, Macrae, Finlay A
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Adult Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Biopsy Blood Bone marrow Crohn Disease - drug therapy Crohn's disease Digestive system diseases Drug dosages Fatal Outcome FDA approval Hematologic diseases Hematology Hemoglobin Humans Hypotension Immunologic Factors - adverse effects Immunologic Factors - therapeutic use Immunomodulators Immunotherapy Inflammatory bowel disease Infliximab Leukocytes Liver Liver Neoplasms - chemically induced Lymphoma Lymphoma, T-Cell - chemically induced Male Neutrophils Patients Pharmaceutical preparations Rheumatoid arthritis Splenic Neoplasms - chemically induced TNF inhibitors Tomography Transplants & implants Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor necrosis factor-TNF
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Zusammenfassung:	Tumour necrosis factor inhibitors have revolutionised the management of Crohn's disease, but reports of a possible association between concomitant infliximab and immunomodulator therapy and hepatosplenic T-cell lymphoma (a rare form of aggressive non-Hodgkin's lymphoma) have emerged. We describe the first case in Australia of hepatosplenic T-cell lymphoma in a patient who had been treated with infliximab and immunomodulators for Crohn's disease.
ISSN:	0025-729X 1326-5377
DOI:	10.5694/j.1326-5377.2008.tb02124.x