High-dose dexamethasone therapy as the initial treatment for idiopathic thrombocytopenic purpura

There is a controversy which short term high dose dexamethasone therapy (HDD) or standard dose prednisolone therapy as the initial treatment leads to long term efficacy in idiopathic thrombocytopenic purpura (ITP) patients. We conducted a multicenter, prospective trial to determine the efficacy and...

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Veröffentlicht in:	International journal of hematology 2020-03, Vol.111 (3), p.388-395
Hauptverfasser:	Takase, Ken, Nagai, Hirokazu, Kadono, Moe, Yoshioka, Takanori, Yoshio, Nobuyuki, Hirabayashi, Yukio, Ito, Takuo, Sawamura, Morio, Yokoyama, Akihiro, Yoshida, Shinichiro, Tsutsumi, Ikuyo, Otsuka, Maki, Suehiro, Youko, Hidaka, Michihiro, Yoshida, Isao, Yokoyama, Hisayuki, Inoue, Hitoshi, Iida, Hiroatsu, Nakayama, Maki, Hishita, Terutoshi, Iwasaki, Hiromi, Kada, Akiko, Saito, Akiko M., Kuroda, Yoshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bleeding Clinical trials Confidence intervals Dexamethasone Dexamethasone - administration & dosage Hematology Humans Idiopathic thrombocytopenic purpura Male Medicine Medicine & Public Health Oncology Original Article Patients Prednisolone Pulse Therapy, Drug Purpura, Thrombocytopenic, Idiopathic - drug therapy Steroids Therapy Thrombocytopenic purpura Treatment Outcome
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Zusammenfassung:	There is a controversy which short term high dose dexamethasone therapy (HDD) or standard dose prednisolone therapy as the initial treatment leads to long term efficacy in idiopathic thrombocytopenic purpura (ITP) patients. We conducted a multicenter, prospective trial to determine the efficacy and safety of short-term HDD in ITP patients aged 18–80 years with platelet counts of
ISSN:	0925-5710 1865-3774
DOI:	10.1007/s12185-019-02808-6