Autologous peripheral blood stem cell transplantation for relapsed/refractory HIV-associated lymphoma: a phase II clinical study

The outcome of relapsed/refractory HIV-associated lymphoma remains poor, even in the era of combined antiretroviral therapy. However, recent reports showed the efficacy of autologous stem cell transplantation (ASCT). We conducted a single-arm, multicenter phase II study in patients with relapsed/ref...

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Veröffentlicht in:International journal of hematology 2020-03, Vol.111 (3), p.434-439
Hauptverfasser: Hagiwara, Shotaro, Nagai, Hirokazu, Uehira, Tomoko, Saito, Akiko M., Okada, Seiji
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Sprache:eng
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Zusammenfassung:The outcome of relapsed/refractory HIV-associated lymphoma remains poor, even in the era of combined antiretroviral therapy. However, recent reports showed the efficacy of autologous stem cell transplantation (ASCT). We conducted a single-arm, multicenter phase II study in patients with relapsed/refractory HIV-associated lymphoma to assess the safety and efficacy of ASCT. The study included 14 patients with relapsed/refractory HIV-associated lymphoma. Five patients who achieved partial remission or better after the standard salvage regimen proceeded to ASCT. Conditioning treatment involved ranimustine (300 mg/m2) on day − 6, etoposide (200 mg/m2) on days − 5 to − 3, cytarabine (200 mg/m2) on days − 5 to − 3, and L-PAM (140 mg/m2) on day − 2. All patients achieved engraftment and were alive on day 100 of ASCT. One-year and 2-year overall survival rates were both 40% and 1-year and 2-year progression-free survival rates were both 40%. Grade 2 or 3 diarrhea and oral mucositis were observed in 43% of patients. Cytomegalovirus antigenemia, retinitis, and bacterial infections were noted in 43%, 29%, and 29% of patients, respectively. Therapy-related death was not observed. Although the number of enrolled patients was insufficient for statistical analysis. ASCT was feasible and safe for relapsed/refractory HIV-associated lymphoma. Registration: This study is registered in UMIN-CTR (UMIN000003159).
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-019-02791-y