Human Renal Carcinoma Line Transfected With Interleukin-2 and/or Interferon   Gene(s): Implications for Live Cancer Vaccines

Human Renal Carcinoma Line Transfected With Interleukin-2 and/or Interferon   Gene(s): Implications for Live Cancer Vaccines

A study found that local production of high concentrations of interleukin-2 and interferon beta genes at the tumor site is more effective in preventing tumor growth than systemic administration. Therefore, continuous local delivery of cytokines via transfer of cytokine genes into tumor cells for use...

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Veröffentlicht in:JNCI : Journal of the National Cancer Institute 1993-02, Vol.85 (3), p.207-216
Hauptverfasser: Belldegrun, A., Tso, C.-L., Sakata, T., Duckett, T., Brunda, M. J., Barsky, S. H., Chai, J., Kaboo, R., Lavey, R. S., McBride, W. H., deKernion, J. B.
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Genes
Kidneys
Medical research
Vaccines
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Zusammenfassung:A study found that local production of high concentrations of interleukin-2 and interferon beta genes at the tumor site is more effective in preventing tumor growth than systemic administration. Therefore, continuous local delivery of cytokines via transfer of cytokine genes into tumor cells for use as live cancer vaccines is a novel strategy for manipulation of host-mediated antitumor response in patients with advance renal cell carcinoma.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/85.3.207