Sexualdimorphismen adulter Stammzellen

Sexualdimorphismen adulter Stammzellen

Neurodegenerative diseases like Parkinson’s disease differ between the sexes in severity and occurrence. Next to hormons, increasing evidence suggests stem cell-intrinsic mechanisms to account for pathologic sex-specific differences. Here, we discuss such sex-related intrinsic mechanisms and sex-spe...

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Veröffentlicht in:Biospektrum 2020-02, Vol.26 (1), p.50-53
Hauptverfasser: Merten, Madlen, Greiner, Johannes F. W., Kaltschmidt, Christian, Kaltschmidt, Barbara
Format: Artikel
Sprache:ger
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Human Genetics
Life Sciences
Microbiology
Pharmacology/Toxicology
Wissenschaft· Special: Stammzellforschung
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Beschreibung
Zusammenfassung:Neurodegenerative diseases like Parkinson’s disease differ between the sexes in severity and occurrence. Next to hormons, increasing evidence suggests stem cell-intrinsic mechanisms to account for pathologic sex-specific differences. Here, we discuss such sex-related intrinsic mechanisms and sex-specific differences in adult stem cells, neuronal development and neuroprotection. The reviewed observations emphazise the importance of considering sexual dimorphisms for medical treatment strategies.
ISSN:0947-0867
1868-6249
DOI:10.1007/s12268-020-1333-2