Tailoring electroactive poly(vinylidene fluoride‐co-trifluoroethylene) microspheres by a nanoprecipitation method

•Electroactive microspheres were prepared by nanoprecipitation.•Microspheres are based on P(VDF-TrFE).•The effect of processing variables on sphere size, morphology and physico-chemical properties was evaluated.•A ratio of 90% methanol/ultrapure water promotes the formation of smooth and stable microspheres.•Microspheres in the electroactive β phase and with a degree of crystallinity ≈26% are obtained. Poly(vinylidene fluoride‐co-trifluoroethylene) (P(VDF-TrFE)) microspheres were obtained by a nanoprecipitation method based on the deposition of a polymeric solution over a non-solvent (NS) solution. The effect of several parameters on sphere formation was evaluated, including copolymer concentration, NS content (methanol/water ratio) and surfactant type. Morphological and physico-chemical characterizations were performed. Depending on processing conditions, spheres with diameters ranging from ~100 to 1100 nm with similar physico-chemical properties were obtained. Independently of the processing conditions, P(VDF-TrFE) microspheres crystallize in the electroactive β phase with an average crystallinity of 26%. Thus, samples show the required characteristics for biomedical applications.