Effect of ultra-processed diet on gut microbiota and thus its role in neurodegenerative diseases
The current dietary pattern is characterized by high consumption of ultra-processed foods and lower consumption of fiber and vegetables, environmental factors that are associated directly with the current incidence of chronic metabolic diseases. Diet is an environmental factor that influences the di...
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Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2020-03, Vol.71, p.110609, Article 110609 |
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Sprache: | eng |
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Zusammenfassung: | The current dietary pattern is characterized by high consumption of ultra-processed foods and lower consumption of fiber and vegetables, environmental factors that are associated directly with the current incidence of chronic metabolic diseases. Diet is an environmental factor that influences the diversity and functionality of the gut microbiota, where dietary changes have a direct action on their homeostasis. The environment created in the gut by ultra-processed foods, a hallmark of the Western diet that are recognized as trigger factors for low-grade systemic inflammatory and oxidative changes, favor the development of neurodegenerative diseases (NDs). From a systematic search, the present review analyzes the relationship and effect of the current feeding pattern, with the dysregulation of the microbiota and its influence on the development of cognitive decline. Because diagnosis of NDs is usually at late stages, this review highlights the importance of a search for stricter public health strategies regarding access to and development of ultra-processed foods.
•Consumption of ultra-processed food increases the risk for presenting with a chronic metabolic disease.•Changes in the gut microbiota composition is related to the development of neurodegenerative diseases.•Diets high in fat and simple carbohydrates are associated with neuroinflammation and reduction in cognitive function.•The state of the intestinal microbiota is a possible clinical marker candidate in the association assessment between neuroinflammation, cognitive decline, and consumption of ultra-processed food. |
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ISSN: | 0899-9007 1873-1244 |
DOI: | 10.1016/j.nut.2019.110609 |