Microwave‐assisted Vilsmeier‐Haack synthesis of Pyrazole‐4‐carbaldehydes

Microwave‐assisted Vilsmeier‐Haack synthesis of Pyrazole‐4‐carbaldehydes

The synthesis of 4‐formylpyrazoles using Vilsmeier‐Haack reagent is a common protocol in pyrazole chemistry. An efficient microwave‐assisted synthesis of 4‐formylpyrazoles by employing Vilsmeier‐Haack reagent (OPC‐VH) derived from phthaloyl dichloride/dimethylformamide has been described. This metho...

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Veröffentlicht in:Journal of heterocyclic chemistry 2020-02, Vol.57 (2), p.796-804
Hauptverfasser: Kumari, Poonam, Sood, Sumit, Kumar, Anil, Singh, Karan
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Chemical synthesis
Dichlorides
Organic chemistry
Pyrazole
Reagents
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container_title Journal of heterocyclic chemistry
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creator Kumari, Poonam
Sood, Sumit
Kumar, Anil
Singh, Karan
description The synthesis of 4‐formylpyrazoles using Vilsmeier‐Haack reagent is a common protocol in pyrazole chemistry. An efficient microwave‐assisted synthesis of 4‐formylpyrazoles by employing Vilsmeier‐Haack reagent (OPC‐VH) derived from phthaloyl dichloride/dimethylformamide has been described. This method offers the advantages of operational simplicity, avoiding the use of POCl3 as toxic reagents and reuse of the by‐product in the preparation of phthaloyl dichloride.
doi_str_mv 10.1002/jhet.3824
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subjects Chemical synthesis
Dichlorides
Organic chemistry
Pyrazole
Reagents
title Microwave‐assisted Vilsmeier‐Haack synthesis of Pyrazole‐4‐carbaldehydes
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