Microwave‐assisted Vilsmeier‐Haack synthesis of Pyrazole‐4‐carbaldehydes

Microwave‐assisted Vilsmeier‐Haack synthesis of Pyrazole‐4‐carbaldehydes

The synthesis of 4‐formylpyrazoles using Vilsmeier‐Haack reagent is a common protocol in pyrazole chemistry. An efficient microwave‐assisted synthesis of 4‐formylpyrazoles by employing Vilsmeier‐Haack reagent (OPC‐VH) derived from phthaloyl dichloride/dimethylformamide has been described. This metho...

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Veröffentlicht in:Journal of heterocyclic chemistry 2020-02, Vol.57 (2), p.796-804
Hauptverfasser: Kumari, Poonam, Sood, Sumit, Kumar, Anil, Singh, Karan
Format: Artikel
Sprache:eng
Schlagworte:
Chemical synthesis
Dichlorides
Organic chemistry
Pyrazole
Reagents
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Zusammenfassung:The synthesis of 4‐formylpyrazoles using Vilsmeier‐Haack reagent is a common protocol in pyrazole chemistry. An efficient microwave‐assisted synthesis of 4‐formylpyrazoles by employing Vilsmeier‐Haack reagent (OPC‐VH) derived from phthaloyl dichloride/dimethylformamide has been described. This method offers the advantages of operational simplicity, avoiding the use of POCl3 as toxic reagents and reuse of the by‐product in the preparation of phthaloyl dichloride.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3824