Behavioural and psychological symptoms of Alzheimer's disease associated with caregiver burden and depression

OBJECTIVE: The aim of the study was to investigate the relationship between behavioural and psychological symptoms of Alzheimer's disease with caregiver burden and depression. METHODS: In this prospective and clinic-based study, 71 patients over 65 years of age diagnosed with Alzheimer's disease according to DSM IV diagnostic criteria who were admitted to Bakirkoy Prof. Dr. Mazhar Osman Research and Training Hospital for Psychiatry, Neurology and Neurosurgery between April 2014 and November 2014 and their 71 care givers were included in the study. Information on patients and caregivers were assessed using the sociodemographic and clinical data form. The Standardized Mini Mental State Examination (SMMSE) and the Global Deterioration Scale (GDS) were used to determine disease severity and stage. The Neuropsychiatric Inventory (NPI) was used to assess the behavioural and psychological symptoms of the patients. Caregivers' burden and depression were assessed using the Zarit Caregiver Burden Scale (ZCBS) and the Hamilton Depression Rating Scale (HAM-D). SPSS 22.0 program was used for the statistical analysis of data. RESULTS: The average age of the caregivers was 52, 81.7% (n: 58) were female and 53.5% (n: 38) were the patients' daughters. Caregiver burden was found to be mild in 50.7% (n: 36), moderate in 15.5% (n: 11) and heavy in 33.8% (n: 24) of caregivers. Depression was found to be mild in 19.7% (n: 14), moderate in 19.7% (n: 14) and severe in 4.2% (n: 3) of caregivers. The most common behavioural and psychological symptoms were; apathy (60.6%), delusions (57.7%), depression / dysphoria (56.3%), hallucinations (53.5%), irritability (47.9%), anxiety (32.4%), abnormal motor behaviour (29.6%), agitation / aggression (26.8%), eating-appetite changes (26.8%) and elation / euphoria (1.4%). Patient caregivers in the group with more behavioural and psychological symptoms had more caregiving burden and depression. Symptoms having a significant effect on caregiver burden were delusions, hallucinations, agitation/aggression, depression/dysphoria, anxiety, apathy, disinhibition, irritability, abnormal motor behaviour. Behavioural and psychological symptoms that correlate with caregiver depression are agitation/aggression, anxiety, disinhibition, irritability. In the correlation analysis between NPE and ZCBS factor groups, only the factor 4 showing the economic burden did not show any significant correlation. CONCLUSION: Results show that behavioural and psychological