The Relationship between Fish Intake and Urinary Trimethylamine‐N‐Oxide

Scope Fish intake is reported to be associated with certain health benefits; however, accurate assessment of fish intake is still problematic. The objective of this study is to identify fish intake biomarkers and examine relationships with health parameters in a free‐living population. Methods and results In the NutriTech study, ten participants randomized into the fish group consume increasing quantities of fish for 3 days per week for 3 weeks. Urine is analyzed by NMR spectroscopy. Trimethylamine‐N‐oxide (TMAO), dimethylamine, and dimethyl sulfone are identified and display significant dose–response with intake (p