Detection in two hospitals of transferable ceftazidimeavibactam resistance in Klebsiella pneumoniae due to a novel VEB β-lactamase variant with a Lys234Arg substitution, Greece, 2019

Two ceftazidime-avibactam (CAZ-AVI)-resistant Klebsiella pneumoniae carbapenemase (KPC)-positive K. pneumoniae strains, including one pandrug resistant, were isolated in 2019 from two Greek hospitals. The strains were sequence types (ST)s 258 and 147 and both harboured similar self-transmissible Inc...

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Veröffentlicht in:	Euro surveillance : bulletin européen sur les maladies transmissibles 2020-01, Vol.25 (2), p.2
Hauptverfasser:	Voulgari, E, Kotsakis, SD, Giannopoulou, P, Perivolioti, E, Tzouvelekis, LS, Miriagou, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial infections E coli Genotype & phenotype Multidrug resistant organisms Plasmids
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Zusammenfassung:	Two ceftazidime-avibactam (CAZ-AVI)-resistant Klebsiella pneumoniae carbapenemase (KPC)-positive K. pneumoniae strains, including one pandrug resistant, were isolated in 2019 from two Greek hospitals. The strains were sequence types (ST)s 258 and 147 and both harboured similar self-transmissible IncA/C2 plasmids encoding a novel Lys234Arg variant of the Vietnamese extended-spectrum β-lactamase (VEB)-1, not inhibited by AVI (VEB-25). Conjugal transfer of VEB-25-encoding plasmids to Escherichia coli yielded CAZ-AVI-resistant clones, supporting that VEB-25 is directly linked to the derived phenotype.
ISSN:	1025-496X 1560-7917
DOI:	10.2807/1560-7917.ES.2020.25.2.1900766