Long-term effectiveness of levodopa-carbidopa intestinal gel in 177 Spanish patients with advanced Parkinson's disease

To assess long-term effectiveness and tolerability of levodopa-carbidopa intestinal gel (LCIG) in Spanish patients with advanced Parkinson's disease. This was an observational, multicenter, cross-sectional, retrospective study. Data of 177 patients were analyzed. LCIG treatment led to a reducti...

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Veröffentlicht in:Neurodegenerative disease management 2016-08, Vol.6 (4), p.289-298
Hauptverfasser: Valldeoriola, Francesc, Grandas, Francisco, Santos-García, Diego, Regidor, Ignacio, Catalán, María José, Arbelo, José Matías, Puente, Víctor, Mir, Pablo, Parra, Juan Carlos
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Sprache:eng
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Zusammenfassung:To assess long-term effectiveness and tolerability of levodopa-carbidopa intestinal gel (LCIG) in Spanish patients with advanced Parkinson's disease. This was an observational, multicenter, cross-sectional, retrospective study. Data of 177 patients were analyzed. LCIG treatment led to a reduction in the percentage of daily 'off' time (16.2 vs 47.6% before LCIG), an increase in the percentage of daily 'on' time without disabling dyskinesia (55.6 vs 21.6%). Most patients experienced improvements in freezing of gait, tremor, dizziness, fatigue or flat mood. Adverse events related to levodopa, gastrostomy and technical issues were reported in 36.2, 42.4 and 43.5% of patients, respectively. This study confirms the long-term effectiveness and safety profile of LCIG in patients with advanced Parkinson's disease.
ISSN:1758-2024
1758-2032
DOI:10.2217/nmt-2016-0021