Impact of active smoking on outcomes in HPV+ oropharyngeal cancer
Background The role of smoking among patients with human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC) is unclear. Methods A retrospective cohort study of patients with HPV(+) OPSCC from 2001 to 2015 at a tertiary‐care institution was conducted. The primary outcome was...
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| Veröffentlicht in: | Head & neck 2020-02, Vol.42 (2), p.269-280 |
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| creator | Xiao, Roy Pham, Yvonne Ward, Matthew C. Houston, Narcissa Reddy, Chandana A. Joshi, Nikhil P. Greskovich, John F. Woody, Neil M. Chute, Deborah J. Lamarre, Eric D. Prendes, Brandon L. Lorenz, Robert R. Scharpf, Joseph Burkey, Brian B. Geiger, Jessica L. Adelstein, David J. Koyfman, Shlomo A. |
| description | Background
The role of smoking among patients with human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC) is unclear.
Methods
A retrospective cohort study of patients with HPV(+) OPSCC from 2001 to 2015 at a tertiary‐care institution was conducted. The primary outcome was overall survival (OS).
Results
Among 484 included patients, 94 (19.4%) were active smokers, 226 (46.7%) were former smokers, and 164 (33.9%) never smoked. Among active smokers, 82 patients (87.2%) had a ≥10 pack‐year and 69 (73.4%) had a ≥20 pack‐year smoking history. After adjusting for covariates, active smoking was a significant predictor of inferior OS (HR 2.28, P |
| doi_str_mv | 10.1002/hed.26001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2339500344</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2339500344</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2681-93156566cbba0869595ead542015ac2c851b8df8d07f3c14bc254e0d50790f393</originalsourceid><addsrcrecordid>eNp1kE1PAjEQhhujEUUP_gHTxJMxC9Ov_TgSRCEh0YN6bbrdLiyyW2xZDf_e4sLR0zuZPPPOzIvQDYEBAaDDpSkGNAYgJ-iCQJZEwHhyuq85ixgkvIcuvV8BAIs5PUc9RpI4C6MXaDSrN0pvsS1xkOrbYF_bz6pZYNtg2261rY3HVYOnrx8P2Dq7WSq3axZGrbFWjTbuCp2Vau3N9UH76P1p8jaeRvOX59l4NI80jVMSZYyIWMSxznMFaZyJTBhVCE6BCKWpTgXJ06JMC0hKpgnPNRXcQCEgyaBkGeuju8534-xXa_xWrmzrmrBSUsYyEZ7jPFD3HaWd9d6ZUm5cVYeTJQG5D0uGsORfWIG9PTi2eR26R_KYTgCGHfBTrc3ufyc5nTx2lr8NEHCd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2339500344</pqid></control><display><type>article</type><title>Impact of active smoking on outcomes in HPV+ oropharyngeal cancer</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Xiao, Roy ; Pham, Yvonne ; Ward, Matthew C. ; Houston, Narcissa ; Reddy, Chandana A. ; Joshi, Nikhil P. ; Greskovich, John F. ; Woody, Neil M. ; Chute, Deborah J. ; Lamarre, Eric D. ; Prendes, Brandon L. ; Lorenz, Robert R. ; Scharpf, Joseph ; Burkey, Brian B. ; Geiger, Jessica L. ; Adelstein, David J. ; Koyfman, Shlomo A.</creator><creatorcontrib>Xiao, Roy ; Pham, Yvonne ; Ward, Matthew C. ; Houston, Narcissa ; Reddy, Chandana A. ; Joshi, Nikhil P. ; Greskovich, John F. ; Woody, Neil M. ; Chute, Deborah J. ; Lamarre, Eric D. ; Prendes, Brandon L. ; Lorenz, Robert R. ; Scharpf, Joseph ; Burkey, Brian B. ; Geiger, Jessica L. ; Adelstein, David J. ; Koyfman, Shlomo A.</creatorcontrib><description>Background
The role of smoking among patients with human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC) is unclear.
Methods
A retrospective cohort study of patients with HPV(+) OPSCC from 2001 to 2015 at a tertiary‐care institution was conducted. The primary outcome was overall survival (OS).
Results
Among 484 included patients, 94 (19.4%) were active smokers, 226 (46.7%) were former smokers, and 164 (33.9%) never smoked. Among active smokers, 82 patients (87.2%) had a ≥10 pack‐year and 69 (73.4%) had a ≥20 pack‐year smoking history. After adjusting for covariates, active smoking was a significant predictor of inferior OS (HR 2.28, P < .001) and PFS (HR 2.26, P < .001). When including pack‐years as the covariate, ≥20 pack‐years predicted a decreased effect‐size for inferior OS and PFS.
Conclusions
For patients with HPV(+) OPSCC, active smoking at diagnosis is the most powerful covariate capturing smoking history to predict OS and PFS.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.26001</identifier><identifier>PMID: 31769100</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Head and neck ; Human papillomavirus ; Oropharyngeal cancer ; overall survival ; pack‐years ; Smoking ; smoking status ; Squamous cell carcinoma ; Throat cancer ; Tobacco smoke</subject><ispartof>Head & neck, 2020-02, Vol.42 (2), p.269-280</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2681-93156566cbba0869595ead542015ac2c851b8df8d07f3c14bc254e0d50790f393</citedby><cites>FETCH-LOGICAL-c2681-93156566cbba0869595ead542015ac2c851b8df8d07f3c14bc254e0d50790f393</cites><orcidid>0000-0003-4459-0746</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.26001$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.26001$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31769100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiao, Roy</creatorcontrib><creatorcontrib>Pham, Yvonne</creatorcontrib><creatorcontrib>Ward, Matthew C.</creatorcontrib><creatorcontrib>Houston, Narcissa</creatorcontrib><creatorcontrib>Reddy, Chandana A.</creatorcontrib><creatorcontrib>Joshi, Nikhil P.</creatorcontrib><creatorcontrib>Greskovich, John F.</creatorcontrib><creatorcontrib>Woody, Neil M.</creatorcontrib><creatorcontrib>Chute, Deborah J.</creatorcontrib><creatorcontrib>Lamarre, Eric D.</creatorcontrib><creatorcontrib>Prendes, Brandon L.</creatorcontrib><creatorcontrib>Lorenz, Robert R.</creatorcontrib><creatorcontrib>Scharpf, Joseph</creatorcontrib><creatorcontrib>Burkey, Brian B.</creatorcontrib><creatorcontrib>Geiger, Jessica L.</creatorcontrib><creatorcontrib>Adelstein, David J.</creatorcontrib><creatorcontrib>Koyfman, Shlomo A.</creatorcontrib><title>Impact of active smoking on outcomes in HPV+ oropharyngeal cancer</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
The role of smoking among patients with human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC) is unclear.
Methods
A retrospective cohort study of patients with HPV(+) OPSCC from 2001 to 2015 at a tertiary‐care institution was conducted. The primary outcome was overall survival (OS).
Results
Among 484 included patients, 94 (19.4%) were active smokers, 226 (46.7%) were former smokers, and 164 (33.9%) never smoked. Among active smokers, 82 patients (87.2%) had a ≥10 pack‐year and 69 (73.4%) had a ≥20 pack‐year smoking history. After adjusting for covariates, active smoking was a significant predictor of inferior OS (HR 2.28, P < .001) and PFS (HR 2.26, P < .001). When including pack‐years as the covariate, ≥20 pack‐years predicted a decreased effect‐size for inferior OS and PFS.
Conclusions
For patients with HPV(+) OPSCC, active smoking at diagnosis is the most powerful covariate capturing smoking history to predict OS and PFS.</description><subject>Head and neck</subject><subject>Human papillomavirus</subject><subject>Oropharyngeal cancer</subject><subject>overall survival</subject><subject>pack‐years</subject><subject>Smoking</subject><subject>smoking status</subject><subject>Squamous cell carcinoma</subject><subject>Throat cancer</subject><subject>Tobacco smoke</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kE1PAjEQhhujEUUP_gHTxJMxC9Ov_TgSRCEh0YN6bbrdLiyyW2xZDf_e4sLR0zuZPPPOzIvQDYEBAaDDpSkGNAYgJ-iCQJZEwHhyuq85ixgkvIcuvV8BAIs5PUc9RpI4C6MXaDSrN0pvsS1xkOrbYF_bz6pZYNtg2261rY3HVYOnrx8P2Dq7WSq3axZGrbFWjTbuCp2Vau3N9UH76P1p8jaeRvOX59l4NI80jVMSZYyIWMSxznMFaZyJTBhVCE6BCKWpTgXJ06JMC0hKpgnPNRXcQCEgyaBkGeuju8534-xXa_xWrmzrmrBSUsYyEZ7jPFD3HaWd9d6ZUm5cVYeTJQG5D0uGsORfWIG9PTi2eR26R_KYTgCGHfBTrc3ufyc5nTx2lr8NEHCd</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Xiao, Roy</creator><creator>Pham, Yvonne</creator><creator>Ward, Matthew C.</creator><creator>Houston, Narcissa</creator><creator>Reddy, Chandana A.</creator><creator>Joshi, Nikhil P.</creator><creator>Greskovich, John F.</creator><creator>Woody, Neil M.</creator><creator>Chute, Deborah J.</creator><creator>Lamarre, Eric D.</creator><creator>Prendes, Brandon L.</creator><creator>Lorenz, Robert R.</creator><creator>Scharpf, Joseph</creator><creator>Burkey, Brian B.</creator><creator>Geiger, Jessica L.</creator><creator>Adelstein, David J.</creator><creator>Koyfman, Shlomo A.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0003-4459-0746</orcidid></search><sort><creationdate>202002</creationdate><title>Impact of active smoking on outcomes in HPV+ oropharyngeal cancer</title><author>Xiao, Roy ; Pham, Yvonne ; Ward, Matthew C. ; Houston, Narcissa ; Reddy, Chandana A. ; Joshi, Nikhil P. ; Greskovich, John F. ; Woody, Neil M. ; Chute, Deborah J. ; Lamarre, Eric D. ; Prendes, Brandon L. ; Lorenz, Robert R. ; Scharpf, Joseph ; Burkey, Brian B. ; Geiger, Jessica L. ; Adelstein, David J. ; Koyfman, Shlomo A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2681-93156566cbba0869595ead542015ac2c851b8df8d07f3c14bc254e0d50790f393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Head and neck</topic><topic>Human papillomavirus</topic><topic>Oropharyngeal cancer</topic><topic>overall survival</topic><topic>pack‐years</topic><topic>Smoking</topic><topic>smoking status</topic><topic>Squamous cell carcinoma</topic><topic>Throat cancer</topic><topic>Tobacco smoke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Roy</creatorcontrib><creatorcontrib>Pham, Yvonne</creatorcontrib><creatorcontrib>Ward, Matthew C.</creatorcontrib><creatorcontrib>Houston, Narcissa</creatorcontrib><creatorcontrib>Reddy, Chandana A.</creatorcontrib><creatorcontrib>Joshi, Nikhil P.</creatorcontrib><creatorcontrib>Greskovich, John F.</creatorcontrib><creatorcontrib>Woody, Neil M.</creatorcontrib><creatorcontrib>Chute, Deborah J.</creatorcontrib><creatorcontrib>Lamarre, Eric D.</creatorcontrib><creatorcontrib>Prendes, Brandon L.</creatorcontrib><creatorcontrib>Lorenz, Robert R.</creatorcontrib><creatorcontrib>Scharpf, Joseph</creatorcontrib><creatorcontrib>Burkey, Brian B.</creatorcontrib><creatorcontrib>Geiger, Jessica L.</creatorcontrib><creatorcontrib>Adelstein, David J.</creatorcontrib><creatorcontrib>Koyfman, Shlomo A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Roy</au><au>Pham, Yvonne</au><au>Ward, Matthew C.</au><au>Houston, Narcissa</au><au>Reddy, Chandana A.</au><au>Joshi, Nikhil P.</au><au>Greskovich, John F.</au><au>Woody, Neil M.</au><au>Chute, Deborah J.</au><au>Lamarre, Eric D.</au><au>Prendes, Brandon L.</au><au>Lorenz, Robert R.</au><au>Scharpf, Joseph</au><au>Burkey, Brian B.</au><au>Geiger, Jessica L.</au><au>Adelstein, David J.</au><au>Koyfman, Shlomo A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of active smoking on outcomes in HPV+ oropharyngeal cancer</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2020-02</date><risdate>2020</risdate><volume>42</volume><issue>2</issue><spage>269</spage><epage>280</epage><pages>269-280</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
The role of smoking among patients with human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC) is unclear.
Methods
A retrospective cohort study of patients with HPV(+) OPSCC from 2001 to 2015 at a tertiary‐care institution was conducted. The primary outcome was overall survival (OS).
Results
Among 484 included patients, 94 (19.4%) were active smokers, 226 (46.7%) were former smokers, and 164 (33.9%) never smoked. Among active smokers, 82 patients (87.2%) had a ≥10 pack‐year and 69 (73.4%) had a ≥20 pack‐year smoking history. After adjusting for covariates, active smoking was a significant predictor of inferior OS (HR 2.28, P < .001) and PFS (HR 2.26, P < .001). When including pack‐years as the covariate, ≥20 pack‐years predicted a decreased effect‐size for inferior OS and PFS.
Conclusions
For patients with HPV(+) OPSCC, active smoking at diagnosis is the most powerful covariate capturing smoking history to predict OS and PFS.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31769100</pmid><doi>10.1002/hed.26001</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-4459-0746</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Head and neck Human papillomavirus Oropharyngeal cancer overall survival pack‐years Smoking smoking status Squamous cell carcinoma Throat cancer Tobacco smoke |
| title | Impact of active smoking on outcomes in HPV+ oropharyngeal cancer |
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