Impact of active smoking on outcomes in HPV+ oropharyngeal cancer

Impact of active smoking on outcomes in HPV+ oropharyngeal cancer

Background The role of smoking among patients with human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC) is unclear. Methods A retrospective cohort study of patients with HPV(+) OPSCC from 2001 to 2015 at a tertiary‐care institution was conducted. The primary outcome was...

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Veröffentlicht in:Head & neck 2020-02, Vol.42 (2), p.269-280
Hauptverfasser: Xiao, Roy, Pham, Yvonne, Ward, Matthew C., Houston, Narcissa, Reddy, Chandana A., Joshi, Nikhil P., Greskovich, John F., Woody, Neil M., Chute, Deborah J., Lamarre, Eric D., Prendes, Brandon L., Lorenz, Robert R., Scharpf, Joseph, Burkey, Brian B., Geiger, Jessica L., Adelstein, David J., Koyfman, Shlomo A.
Format: Artikel
Sprache:eng
Schlagworte:
Head and neck
Human papillomavirus
Oropharyngeal cancer
overall survival
pack‐years
Smoking
smoking status
Squamous cell carcinoma
Throat cancer
Tobacco smoke
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Zusammenfassung:Background The role of smoking among patients with human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC) is unclear. Methods A retrospective cohort study of patients with HPV(+) OPSCC from 2001 to 2015 at a tertiary‐care institution was conducted. The primary outcome was overall survival (OS). Results Among 484 included patients, 94 (19.4%) were active smokers, 226 (46.7%) were former smokers, and 164 (33.9%) never smoked. Among active smokers, 82 patients (87.2%) had a ≥10 pack‐year and 69 (73.4%) had a ≥20 pack‐year smoking history. After adjusting for covariates, active smoking was a significant predictor of inferior OS (HR 2.28, P 
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26001