Increased expression of tumor necrosis factor-alpha receptors in the brains of patients with AIDS

A study was conducted to determine the cellular localization and degree of protein and mRNA expression of the two specific tumor necrosis factor-alpha receptors (TNF-alphaRs), p55 and p75, in brain tissues from AIDS patients. The up-regulation of both TNF-alphaRs in AIDS suggests that macrophages an...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 1995-12, Vol.10 (5), p.511
Hauptverfasser:	Sippy, Brian D, Hofman, Florence M, Wallach, David, Hinton, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Brain Cellular biology Medical research Tumors
Online-Zugang:	Volltext
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Zusammenfassung:	A study was conducted to determine the cellular localization and degree of protein and mRNA expression of the two specific tumor necrosis factor-alpha receptors (TNF-alphaRs), p55 and p75, in brain tissues from AIDS patients. The up-regulation of both TNF-alphaRs in AIDS suggests that macrophages and microglial cells could be important in amplifying the TNF-alpha response.
ISSN:	1525-4135 1944-7884