Inhibition of morphine-potentiated HIV-1 replication in peripheral blood mononuclear cells with the nuclease-resistant 2-5A agonist, 2-5AN6B

Inhibition of morphine-potentiated HIV-1 replication in peripheral blood mononuclear cells with the nuclease-resistant 2-5A agonist, 2-5AN6B

The authors show that restoration of a key component of the antiviral pathway reverses morphine-potentiated HIV-1 infection of human peripheral blood mononuclear cells. The data show that HIV-1 replication is potentiated and RNase L activity is inhibited after morphine administration.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of acquired immune deficiency syndromes (1999) 2002-05, Vol.30 (1), p.9
Hauptverfasser: Homan, Joseph W, Steele, Amber D, Martinand-Mari, Camille, Rogers, Thomas J
Format: Artikel
Sprache:eng
Schlagworte:
Cells
HIV
Human immunodeficiency virus
Medical research
Narcotics
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Beschreibung
Zusammenfassung:The authors show that restoration of a key component of the antiviral pathway reverses morphine-potentiated HIV-1 infection of human peripheral blood mononuclear cells. The data show that HIV-1 replication is potentiated and RNase L activity is inhibited after morphine administration.
ISSN:1525-4135
1944-7884