An automated synthesis method for 68Ga-labelled ubiquicidin 29–41
Published methods for radiolabelling of 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) 29–41 to date describe manual or kit-based procedures. The purpose of this study was to develop an automated synthesis method for the synthesis of [ 68 Ga]Ga-NOTA-UBI. NOTA-UBI was successfull...
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| Veröffentlicht in: | Journal of radioanalytical and nuclear chemistry 2020, Vol.323 (1), p.105-116 |
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| container_title | Journal of radioanalytical and nuclear chemistry |
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| creator | le Roux, Jannie Rubow, Sietske Ebenhan, Thomas Wagener, Carl |
| description | Published methods for radiolabelling of 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) 29–41 to date describe manual or kit-based procedures. The purpose of this study was to develop an automated synthesis method for the synthesis of [
68
Ga]Ga-NOTA-UBI. NOTA-UBI was successfully labelled with gallium-68 using three different automated procedures. The use of radical scavengers to improve radiochemical purity is also discussed. The automated procedures showed a high degree of robustness and repeatability. The validated automated synthesis protocols using a Scintomics GRP Module will contribute to provide GMP-compliant [
68
Ga]Ga-NOTA-UBI for clinical infection imaging. |
| doi_str_mv | 10.1007/s10967-019-06910-1 |
| format | Article |
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68
Ga]Ga-NOTA-UBI. NOTA-UBI was successfully labelled with gallium-68 using three different automated procedures. The use of radical scavengers to improve radiochemical purity is also discussed. The automated procedures showed a high degree of robustness and repeatability. The validated automated synthesis protocols using a Scintomics GRP Module will contribute to provide GMP-compliant [
68
Ga]Ga-NOTA-UBI for clinical infection imaging.</description><identifier>ISSN: 0236-5731</identifier><identifier>EISSN: 1588-2780</identifier><identifier>DOI: 10.1007/s10967-019-06910-1</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Automation ; Chemistry ; Chemistry and Materials Science ; Diagnostic Radiology ; Gallium ; Hadrons ; Heavy Ions ; Inorganic Chemistry ; Nuclear Chemistry ; Nuclear Physics ; Physical Chemistry ; Radiochemistry ; Radiolabelling ; Synthesis</subject><ispartof>Journal of radioanalytical and nuclear chemistry, 2020, Vol.323 (1), p.105-116</ispartof><rights>Akadémiai Kiadó, Budapest, Hungary 2019</rights><rights>Copyright Springer Nature B.V. 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1641-2d7e8fd16ac73ffb7af3946bb10fdcc478695df3c2da63a5621ff9b8bb72396d3</citedby><cites>FETCH-LOGICAL-c1641-2d7e8fd16ac73ffb7af3946bb10fdcc478695df3c2da63a5621ff9b8bb72396d3</cites><orcidid>0000-0001-5075-3236</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10967-019-06910-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10967-019-06910-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>le Roux, Jannie</creatorcontrib><creatorcontrib>Rubow, Sietske</creatorcontrib><creatorcontrib>Ebenhan, Thomas</creatorcontrib><creatorcontrib>Wagener, Carl</creatorcontrib><title>An automated synthesis method for 68Ga-labelled ubiquicidin 29–41</title><title>Journal of radioanalytical and nuclear chemistry</title><addtitle>J Radioanal Nucl Chem</addtitle><description>Published methods for radiolabelling of 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) 29–41 to date describe manual or kit-based procedures. The purpose of this study was to develop an automated synthesis method for the synthesis of [
68
Ga]Ga-NOTA-UBI. NOTA-UBI was successfully labelled with gallium-68 using three different automated procedures. The use of radical scavengers to improve radiochemical purity is also discussed. The automated procedures showed a high degree of robustness and repeatability. The validated automated synthesis protocols using a Scintomics GRP Module will contribute to provide GMP-compliant [
68
Ga]Ga-NOTA-UBI for clinical infection imaging.</description><subject>Automation</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Diagnostic Radiology</subject><subject>Gallium</subject><subject>Hadrons</subject><subject>Heavy Ions</subject><subject>Inorganic Chemistry</subject><subject>Nuclear Chemistry</subject><subject>Nuclear Physics</subject><subject>Physical Chemistry</subject><subject>Radiochemistry</subject><subject>Radiolabelling</subject><subject>Synthesis</subject><issn>0236-5731</issn><issn>1588-2780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kL1OwzAURi0EEqXwAkyRmA2-duKfsaqgIFVigdnyL02VJq2dDN14B96QJyEQJDamu5zzXekgdA3kFggRdxmI4gITUJhwBQTDCZpBJSWmQpJTNCOUcVwJBufoIuctIURJyWZouWgLM_TdzvTBF_nY9puQ61zsQr_pfBG7VHC5MrgxNjTNiAy2Pgy1q33dFlR9vn-UcInOomlyuPq9c_T6cP-yfMTr59XTcrHGDngJmHoRZPTAjRMsRitMZKrk1gKJ3rlSSK4qH5mj3nBmKk4hRmWltYIyxT2bo5tpd5-6wxByr7fdkNrxpaaMjQijgo8UnSiXupxTiHqf6p1JRw1Ef8fSUyw9xtI_sTSMEpukPMLtW0h_0_9YX4_1bJU</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>le Roux, Jannie</creator><creator>Rubow, Sietske</creator><creator>Ebenhan, Thomas</creator><creator>Wagener, Carl</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-5075-3236</orcidid></search><sort><creationdate>2020</creationdate><title>An automated synthesis method for 68Ga-labelled ubiquicidin 29–41</title><author>le Roux, Jannie ; Rubow, Sietske ; Ebenhan, Thomas ; Wagener, Carl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1641-2d7e8fd16ac73ffb7af3946bb10fdcc478695df3c2da63a5621ff9b8bb72396d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Automation</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Diagnostic Radiology</topic><topic>Gallium</topic><topic>Hadrons</topic><topic>Heavy Ions</topic><topic>Inorganic Chemistry</topic><topic>Nuclear Chemistry</topic><topic>Nuclear Physics</topic><topic>Physical Chemistry</topic><topic>Radiochemistry</topic><topic>Radiolabelling</topic><topic>Synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>le Roux, Jannie</creatorcontrib><creatorcontrib>Rubow, Sietske</creatorcontrib><creatorcontrib>Ebenhan, Thomas</creatorcontrib><creatorcontrib>Wagener, Carl</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>le Roux, Jannie</au><au>Rubow, Sietske</au><au>Ebenhan, Thomas</au><au>Wagener, Carl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An automated synthesis method for 68Ga-labelled ubiquicidin 29–41</atitle><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle><stitle>J Radioanal Nucl Chem</stitle><date>2020</date><risdate>2020</risdate><volume>323</volume><issue>1</issue><spage>105</spage><epage>116</epage><pages>105-116</pages><issn>0236-5731</issn><eissn>1588-2780</eissn><abstract>Published methods for radiolabelling of 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) 29–41 to date describe manual or kit-based procedures. The purpose of this study was to develop an automated synthesis method for the synthesis of [
68
Ga]Ga-NOTA-UBI. NOTA-UBI was successfully labelled with gallium-68 using three different automated procedures. The use of radical scavengers to improve radiochemical purity is also discussed. The automated procedures showed a high degree of robustness and repeatability. The validated automated synthesis protocols using a Scintomics GRP Module will contribute to provide GMP-compliant [
68
Ga]Ga-NOTA-UBI for clinical infection imaging.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s10967-019-06910-1</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-5075-3236</orcidid></addata></record> |
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| subjects | Automation Chemistry Chemistry and Materials Science Diagnostic Radiology Gallium Hadrons Heavy Ions Inorganic Chemistry Nuclear Chemistry Nuclear Physics Physical Chemistry Radiochemistry Radiolabelling Synthesis |
| title | An automated synthesis method for 68Ga-labelled ubiquicidin 29–41 |
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