An automated synthesis method for 68Ga-labelled ubiquicidin 29–41

An automated synthesis method for 68Ga-labelled ubiquicidin 29–41

Published methods for radiolabelling of 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) 29–41 to date describe manual or kit-based procedures. The purpose of this study was to develop an automated synthesis method for the synthesis of [ 68 Ga]Ga-NOTA-UBI. NOTA-UBI was successfull...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of radioanalytical and nuclear chemistry 2020, Vol.323 (1), p.105-116
Hauptverfasser: le Roux, Jannie, Rubow, Sietske, Ebenhan, Thomas, Wagener, Carl
Format: Artikel
Sprache:eng
Schlagworte:
Automation
Chemistry
Chemistry and Materials Science
Diagnostic Radiology
Gallium
Hadrons
Heavy Ions
Inorganic Chemistry
Nuclear Chemistry
Nuclear Physics
Physical Chemistry
Radiochemistry
Radiolabelling
Synthesis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Published methods for radiolabelling of 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) 29–41 to date describe manual or kit-based procedures. The purpose of this study was to develop an automated synthesis method for the synthesis of [ 68 Ga]Ga-NOTA-UBI. NOTA-UBI was successfully labelled with gallium-68 using three different automated procedures. The use of radical scavengers to improve radiochemical purity is also discussed. The automated procedures showed a high degree of robustness and repeatability. The validated automated synthesis protocols using a Scintomics GRP Module will contribute to provide GMP-compliant [ 68 Ga]Ga-NOTA-UBI for clinical infection imaging.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-019-06910-1