Transition-metal-free lactamization of C(sp3)–H bonds with CO2: facile generation of pyrido[1,2-a]pyrimidin-4-ones

Transition-metal-free lactamization of C(sp3)–H bonds with CO2: facile generation of pyrido[1,2-a]pyrimidin-4-ones

A novel carbonylation of C(sp3)–H bonds in pyridylamines with one atmosphere of CO2 is reported to synthesize important pyrimidinones in good yields. This transition-metal-free and redox-neutral process features the use of a nontoxic carbonyl source, broad substrate scope, good functional group tole...

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Veröffentlicht in:Green chemistry : an international journal and green chemistry resource : GC 2020, Vol.22 (1), p.28-32
Hauptverfasser: Zhang, Zhen, Xiao-Yu, Zhou, Jin-Gui, Wu, Song, Lei, Da-Gang, Yu
Format: Artikel
Sprache:eng
Schlagworte:
Carbon dioxide
Carbonyl compounds
Carbonyls
Functional groups
Green chemistry
Substrates
Transition metals
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Zusammenfassung:A novel carbonylation of C(sp3)–H bonds in pyridylamines with one atmosphere of CO2 is reported to synthesize important pyrimidinones in good yields. This transition-metal-free and redox-neutral process features the use of a nontoxic carbonyl source, broad substrate scope, good functional group tolerance, facile scalability and easy product derivatization.
ISSN:1463-9262
1463-9270
DOI:10.1039/c9gc03659h