Modification of an Anion-Exchange Procedure for 68Ga Preconcentration and Automated Synthesis of [68Ga]Ga-PSMA-11

An anion-exchange procedure for concentrating 68 Ga produced from a 68 Ga/ 68 Ge generator (Cyclotron Company, Russia) was studied systematically. The procedure for preparing [ 68 Ga]Ga-PSMA-11 of the quality meeting all the requirements for clinical use in a high yield (58 ± 3% or the activity elut...

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Veröffentlicht in:	Radiochemistry (New York, N.Y.) N.Y.), 2019, Vol.61 (6), p.748-753
Hauptverfasser:	Antuganov, D. O., Ryzhkova, D. V., Timofeev, V. V., Zykova, T. A., Antuganova, Yu. O., Timofeeva, K. Yu, Samburov, O. P., Zykov, M. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anion exchanging Automation Chemistry Chemistry and Materials Science Chemistry/Food Science Cyclotrons Medical research Nuclear Chemistry Synthesis
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	An anion-exchange procedure for concentrating 68 Ga produced from a 68 Ga/ 68 Ge generator (Cyclotron Company, Russia) was studied systematically. The procedure for preparing [ 68 Ga]Ga-PSMA-11 of the quality meeting all the requirements for clinical use in a high yield (58 ± 3% or the activity eluted from the generator, n = 10) was developed. Synthesis of [ 68 Ga]Ga-PSMA-11 was performed on an automated unit designed at the Almazov National Medical Research Centre.
ISSN:	1066-3622 1608-3288
DOI:	10.1134/S1066362219060183