HLA-B51 and cigarette smoking as risk factors for chronic progressive neurological manifestations in Behçet's disease

Central nervous system involvement in Behcet's disease (BD) (neuro-Behcet's syndrome; NB) is usually life-threatening, and requires aggressive therapy. The most common manifestation of NB includes cranial nerve palsy, dysarthria, pyramidal tract signs, and ataxia with or without consciousness disturbances. Recent studies have disclosed that NB can be classied into acute type and chronic progressive type according to the clinical course.