Metal‐Free C3 Hydroxylation of Quinoxalin‐2(1H)‐ones in Water

Metal‐Free C3 Hydroxylation of Quinoxalin‐2(1H)‐ones in Water

A practical protocol for the preparation of quinoxaline‐2,3(1H,4H)‐diones through direct C(sp2)−H hydroxylation of quinoxalin‐2(1H)‐ones in recyclable DL‐α‐Tocopherol methoxypolyethylene glycol succinate solution (2 wt% in water) (TPGS‐750‐M/H2O) was developed. The target products were exclusively g...

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Veröffentlicht in:Advanced synthesis & catalysis 2019-12, Vol.361 (24), p.5721-5726
Hauptverfasser: Peng, Sha, Hu, Die, Hu, Jia‐Li, Lin, Ying‐Wu, Tang, Shan‐Shan, Tang, Hai‐Shan, He, Jun‐Yi, Cao, Zhong, He, Wei‐Min
Format: Artikel
Sprache:eng
Schlagworte:
green chemistry
Hydroxylation
in water
quinoxalin-2(1H)-one
Quinoxalines
Recrystallization
Tocopherol
TPGS-750-M
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Zusammenfassung:A practical protocol for the preparation of quinoxaline‐2,3(1H,4H)‐diones through direct C(sp2)−H hydroxylation of quinoxalin‐2(1H)‐ones in recyclable DL‐α‐Tocopherol methoxypolyethylene glycol succinate solution (2 wt% in water) (TPGS‐750‐M/H2O) was developed. The target products were exclusively generated and could be collected through extraction and recrystallization.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201901163