A rat gastrin-human gastrin chimeric transgene directs antral G cell-specific expression in transgenic mice

To determine whether specific promoter elements can direct expression to the gastric antrum in vivo, 450 nucleotides of the proximal rat gastrin promoter were cloned and used to construct a rat gastrin-human gastrin reporter chimeric transgene, which was injected into the mouse germ line.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 1995-06, Vol.31 (6), p.G1025-G1036
Hauptverfasser:	WANG, T. C, BABYATSKY, M. W, OATES, P. S, ZHANG, Z, TILLOTSON, L, CHULAK, M, BRAND, S. J, SCHMIDT, E. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Gastrointestinal hormones Genetics Rodents Stomach Vertebrates: digestive system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	To determine whether specific promoter elements can direct expression to the gastric antrum in vivo, 450 nucleotides of the proximal rat gastrin promoter were cloned and used to construct a rat gastrin-human gastrin reporter chimeric transgene, which was injected into the mouse germ line.
ISSN:	0193-1857 1522-1547