CCK-evoked hyperemia in rat gastric mucosa involves neural mechanisms and nitric oxide

A study was conducted to identify the possible neural mechanisms and mediators that underlie the gastric mucosal hyperemia evoked by cholecystokinin octapeptide (CCK-8) in rats. The gastric vasodilator effect of submaximal doses of CCK-8 is brought about by a vagovagal reflex that involves acetylcho...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 1996-02, Vol.33 (2), p.G253-G258
Hauptverfasser:	HEINEMANN, A, JOCIC, M, PESKAR, B. M, HOLZER, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and medical sciences Fundamental and applied biological sciences. Psychology Metabolism Peptides Rodents Stomach Vertebrates: digestive system
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Beschreibung
Zusammenfassung:	A study was conducted to identify the possible neural mechanisms and mediators that underlie the gastric mucosal hyperemia evoked by cholecystokinin octapeptide (CCK-8) in rats. The gastric vasodilator effect of submaximal doses of CCK-8 is brought about by a vagovagal reflex that involves acetylcholine, the antagonistic calcitonin gene-related peptide or a related peptide, and nitric oxide as vasodilator messengers.
ISSN:	0193-1857 1522-1547