Pancreatic trypsinogen I expression during cell growth and differentiation of two human colon carcinoma cells

Pancreatic trypsin has been found to induce tight junction or dome formation in some colon cancer cell lines (HT-29, Caco-2), and a tumor associated trypsinogen, trypsinogen type II, has been isolated from another colon cancer cell line (COLO205). We have tried to determine if trypsinogen is present...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 1998-06, Vol.37 (6), p.G1077-G1086
Hauptverfasser:	BERNARD-PERRONE, F, CARRERE, J, RENAUD, W, MORISCOT, C, THOREUX, K, BERNARD, P, SERVIN, A, BALAS, D, SENEGAS-BALAS, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cellular biology Colon cancer Gastroenterology. Liver. Pancreas. Abdomen Medical research Medical sciences Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Pancreatic trypsin has been found to induce tight junction or dome formation in some colon cancer cell lines (HT-29, Caco-2), and a tumor associated trypsinogen, trypsinogen type II, has been isolated from another colon cancer cell line (COLO205). We have tried to determine if trypsinogen is present and how its expression varies during cell culture in HT-29 Glc+/- and Caco-2 cells, which exhibit enterocytic: differentiation, and in HT-29 Glc+ cells, which never differentiate.
ISSN:	0193-1857 1522-1547