Impaired gastric acid secretion in gastrin-deficient mice

To further understand the role of the peptide hormone gastrin in the development and function of the stomach, we have generated gastrin-deficient mice by gene targeting in embryonic stem cells. Mutant mice were viable and fertile, without obvious visible abnormalities.

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Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 1998-03, Vol.37 (3), p.G561-G568
Hauptverfasser:	FRIIS-HANSEN, L, SUNDLER, F, YING LI, GILLESPIE, P. J, SAUNDERS, T. L, GREENSON, J. K, OWYANG, C, REHFELD, J. F, SAMUELSON, L. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy & physiology Biological and medical sciences Fundamental and applied biological sciences. Psychology Hormones Rodents Stomach Vertebrates: digestive system
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Beschreibung
Zusammenfassung:	To further understand the role of the peptide hormone gastrin in the development and function of the stomach, we have generated gastrin-deficient mice by gene targeting in embryonic stem cells. Mutant mice were viable and fertile, without obvious visible abnormalities.
ISSN:	0193-1857 1522-1547