COOH-terminally extended secretins are potent stimulants of pancreatic secretion

COOH-terminally extended secretins are potent stimulants of pancreatic secretion

Posttranslational processing of preprosecretin generates several COOH-terminally extended forms of secretin and alpha-carboxyl amidated secretin. We used synthetic canine secretin and analogs with COOH-terminal -amide, -Gly, or -Gly-Lys-Arg to examine the effects of COOH-terminal extensions of secre...

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Veröffentlicht in:American journal of physiology: Gastrointestinal and liver physiology 1999-04, Vol.39 (4), p.G808-G816
Hauptverfasser: SOLOMON, T. E, WALSH, J. H, BUSSJAEGER, L, YUMEI ZONG, HAMILTON, J. W, HO, F. J, LEE, T. D, REEVE, J. R
Format: Artikel
Sprache:eng
Schlagworte:
Anatomy & physiology
Biological and medical sciences
Digestive system
Endocrine system
Exocrine pancreas
Fundamental and applied biological sciences. Psychology
Hormones
Pancreas
Vertebrates: digestive system
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Zusammenfassung:Posttranslational processing of preprosecretin generates several COOH-terminally extended forms of secretin and alpha-carboxyl amidated secretin. We used synthetic canine secretin and analogs with COOH-terminal -amide, -Gly, or -Gly-Lys-Arg to examine the effects of COOH-terminal extensions of secretin on bioactivity and detection in RIA.
ISSN:0193-1857
1522-1547