Delayed rectifier and Ca2+-dependent K+ currents in human esophagus : roles in regulating muscle contraction

We have examined K+ channels and their function in human esophageal smooth muscle using perforated patch recording, RT-PCR to identify channel mRNA, and muscle contraction to study the effects of channel blockers. Depolarization revealed at least two types of currents: a 4-aminopyridine (4-AP)-sensi...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 1999-10, Vol.40 (4), p.G885-G895
Hauptverfasser:	WADE, G. R, LAURIER, L. G, PREIKSAITIS, H. G, SIMS, S. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy & physiology Biological and medical sciences Calcium Digestive system Fundamental and applied biological sciences. Psychology Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus Potassium Vertebrates: digestive system
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Zusammenfassung:	We have examined K+ channels and their function in human esophageal smooth muscle using perforated patch recording, RT-PCR to identify channel mRNA, and muscle contraction to study the effects of channel blockers. Depolarization revealed at least two types of currents: a 4-aminopyridine (4-AP)-sensitive transient delayed rectifier K+ (Kv) and a Ca2+-dependent K+ (KCa) current.
ISSN:	0193-1857 1522-1547