Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice

Regulation of bilirubin glucuronide transporters during hyperbilirubinemia in hepatic and extraliepatic tissues is not completely clear. In the present study, we evaluated the regulation of the bilirubin glucuronide transporters, multidrug resistance-associated proteins (MRP)2 and 3, in rats with ob...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2002-04, Vol.45 (4), p.G656-G662
Hauptverfasser:	TANAKA, Yuji, KOBAYASHI, Yoshinao, GABAZZA, Esteban C, HIGUCHI, Kunihiro, KAMISAKO, Toshinori, KURODA, Makoto, TAKEUCHI, Keisuke, IWASA, Motoh, KAITO, Masahiko, ADACHI, Yukihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Drug resistance Gastroenterology. Liver. Pancreas. Abdomen Kidneys Liver Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Other diseases. Semiology Proteins Rodents
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Zusammenfassung:	Regulation of bilirubin glucuronide transporters during hyperbilirubinemia in hepatic and extraliepatic tissues is not completely clear. In the present study, we evaluated the regulation of the bilirubin glucuronide transporters, multidrug resistance-associated proteins (MRP)2 and 3, in rats with obstructive jaundice. Bile duct ligation (BDL) or sham operation was performed in Wistar rats. Liver and kidneys were removed 1, 3, and 5 days after BDL (n = 4, in each group).
ISSN:	0193-1857 1522-1547