Opposing roles of K+ and Cl- channels in maintenance of opossum lower esophageal sphincter tone

Opposing roles of K+ and Cl- channels in maintenance of opossum lower esophageal sphincter tone

The ionic basis underlying the maintenance of myogenic tone of lower esophageal sphincter circular muscle (LES) was investigated in popssum with the use of standard isometric tension and conventional intracellular microelectrode recordings in vitro. In tension recording studies, nifedipine (1 (mu)M)...

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Veröffentlicht in:American journal of physiology: Gastrointestinal and liver physiology 2000-12, Vol.42 (6), p.G1226-G1234
Hauptverfasser: ZHANG, Yong, MILLER, David V, PATERSON, William G
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Biological and medical sciences
Digestive system
Fundamental and applied biological sciences. Psychology
Marsupials
Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus
Muscular system
Potassium
Vertebrates: digestive system
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Zusammenfassung:The ionic basis underlying the maintenance of myogenic tone of lower esophageal sphincter circular muscle (LES) was investigated in popssum with the use of standard isometric tension and conventional intracellular microelectrode recordings in vitro. In tension recording studies, nifedipine (1 (mu)M) reduced basal tone to 27.7 +/- 3.8% of control.
ISSN:0193-1857
1522-1547