Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis

The initial and rate-limiting step in the classic pathway of bile acid biosynthesis is 7alpha-hydroxylation of cholesterol, a reaction catalyzed by cholesterol 7alpha-=hydroxylase (CYP7A1). The effect of CYP7A1 overexpression on cholesterol homeostasis in human liver cells has not been examined.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2001-10, Vol.44 (4), p.G878-G889
Hauptverfasser:	PANDAK, W. M, SCHWARZ, C, HYLEMON, P. B, MALLONEE, D, VALERIE, K, HEUMAN, D. M, FISHER, R. A, REDFORD, Kaye, VLAHCEVIC, Z. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Bile Biological and medical sciences Cholesterol Effects Fundamental and applied biological sciences. Psychology Liver. Bile. Biliary tracts Medical research Vertebrates: digestive system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The initial and rate-limiting step in the classic pathway of bile acid biosynthesis is 7alpha-hydroxylation of cholesterol, a reaction catalyzed by cholesterol 7alpha-=hydroxylase (CYP7A1). The effect of CYP7A1 overexpression on cholesterol homeostasis in human liver cells has not been examined.
ISSN:	0193-1857 1522-1547