Regulation of apolipoprotein secretion by long-chain polyunsaturated fatty acids in newborn swine enterocytes

Regulation of apolipoprotein secretion by long-chain polyunsaturated fatty acids in newborn swine enterocytes

Long-chain polyunsaturated fatty acids (LC-PUFA) are important in the development of the immature nervous system, and adding these fatty acids to infant formula has been proposed. To determine the effect of n-3 LC-PUFA on apolipoprotein secretion and lipid synthesis in newborn swine enterocytes, dif...

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Veröffentlicht in:American journal of physiology: Gastrointestinal and liver physiology 2001-06, Vol.43 (6), p.G1137-G1144
Hauptverfasser: HENG WANG, SONG LU, JIANHUI DU, YING YAO, BERSCHNEIDER, Helen M, BLACK, Dennis D
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Biological and medical sciences
Fatty acids
Fundamental and applied biological sciences. Psychology
Intestine. Mesentery
Mammals
Phosphates
Proteins
Vertebrates: digestive system
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Zusammenfassung:Long-chain polyunsaturated fatty acids (LC-PUFA) are important in the development of the immature nervous system, and adding these fatty acids to infant formula has been proposed. To determine the effect of n-3 LC-PUFA on apolipoprotein secretion and lipid synthesis in newborn swine enterocytes, differentiated IPEC-1 cells were incubated for 24 h with docosahexaenoic acid (DHA; 22:6) or eicosapentanenoic acid (EPA; 20:5) complexed with albumin at a fatty acid concentration of 0.8 mM or albumin along (control) added to the apical medium.
ISSN:0193-1857
1522-1547