rHuKGF ameliorates symptoms in DSS and CD4+CD45RBHi T cell transfer mouse models of inflammatory bowel disease
There is an acute need for effetive therapy for inflammatory bowel disease IBD particularly at the level of repair of the damaged epithelium. We evaluated the efficacy of recombinant human keratinocyte growth factor (rHuKGF) in both the dextran sodium sulfate (DSS) and the CD4+CD45RBHi T cell transf...
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Veröffentlicht in: | American journal of physiology: Gastrointestinal and liver physiology 2002-04, Vol.45 (4), p.G690-G701 |
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container_title | American journal of physiology: Gastrointestinal and liver physiology |
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creator | BYRNE, Fergus R FARRELL, Catherine L ZIEGLER, Thomas R SENALDI, Giorgio ARANDA, Richard REX, Karen L SCULLY, Sheila BROWN, Heather L FLORES, Silvia A GU, Li H DANILENKO, Dimitry M LACEY, David L |
description | There is an acute need for effetive therapy for inflammatory bowel disease IBD particularly at the level of repair of the damaged epithelium. We evaluated the efficacy of recombinant human keratinocyte growth factor (rHuKGF) in both the dextran sodium sulfate (DSS) and the CD4+CD45RBHi T cell transfer models of IBD. |
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We evaluated the efficacy of recombinant human keratinocyte growth factor (rHuKGF) in both the dextran sodium sulfate (DSS) and the CD4+CD45RBHi T cell transfer models of IBD.</description><identifier>ISSN: 0193-1857</identifier><identifier>EISSN: 1522-1547</identifier><identifier>CODEN: APGPDF</identifier><language>eng</language><publisher>Bethesda, MD: American Physiological Society</publisher><subject>Biological and medical sciences ; Bowel disease ; Digestive system ; Excretory system ; Medical sciences ; Membranes ; Pharmacology. 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We evaluated the efficacy of recombinant human keratinocyte growth factor (rHuKGF) in both the dextran sodium sulfate (DSS) and the CD4+CD45RBHi T cell transfer models of IBD.</description><subject>Biological and medical sciences</subject><subject>Bowel disease</subject><subject>Digestive system</subject><subject>Excretory system</subject><subject>Medical sciences</subject><subject>Membranes</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Rodents</topic><topic>Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BYRNE, Fergus R</creatorcontrib><creatorcontrib>FARRELL, Catherine L</creatorcontrib><creatorcontrib>ZIEGLER, Thomas R</creatorcontrib><creatorcontrib>SENALDI, Giorgio</creatorcontrib><creatorcontrib>ARANDA, Richard</creatorcontrib><creatorcontrib>REX, Karen L</creatorcontrib><creatorcontrib>SCULLY, Sheila</creatorcontrib><creatorcontrib>BROWN, Heather L</creatorcontrib><creatorcontrib>FLORES, Silvia A</creatorcontrib><creatorcontrib>GU, Li H</creatorcontrib><creatorcontrib>DANILENKO, Dimitry M</creatorcontrib><creatorcontrib>LACEY, David L</creatorcontrib><collection>Pascal-Francis</collection><jtitle>American journal of physiology: Gastrointestinal and liver physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BYRNE, Fergus R</au><au>FARRELL, Catherine L</au><au>ZIEGLER, Thomas R</au><au>SENALDI, Giorgio</au><au>ARANDA, Richard</au><au>REX, Karen L</au><au>SCULLY, Sheila</au><au>BROWN, Heather L</au><au>FLORES, Silvia A</au><au>GU, Li H</au><au>DANILENKO, Dimitry M</au><au>LACEY, David L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>rHuKGF ameliorates symptoms in DSS and CD4+CD45RBHi T cell transfer mouse models of inflammatory bowel disease</atitle><jtitle>American journal of physiology: Gastrointestinal and liver physiology</jtitle><date>2002-04-01</date><risdate>2002</risdate><volume>45</volume><issue>4</issue><spage>G690</spage><epage>G701</epage><pages>G690-G701</pages><issn>0193-1857</issn><eissn>1522-1547</eissn><coden>APGPDF</coden><abstract>There is an acute need for effetive therapy for inflammatory bowel disease IBD particularly at the level of repair of the damaged epithelium. We evaluated the efficacy of recombinant human keratinocyte growth factor (rHuKGF) in both the dextran sodium sulfate (DSS) and the CD4+CD45RBHi T cell transfer models of IBD.</abstract><cop>Bethesda, MD</cop><pub>American Physiological Society</pub></addata></record> |
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ispartof | American journal of physiology: Gastrointestinal and liver physiology, 2002-04, Vol.45 (4), p.G690-G701 |
issn | 0193-1857 1522-1547 |
language | eng |
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source | American Physiological Society Paid; EZB-FREE-00999 freely available EZB journals |
subjects | Biological and medical sciences Bowel disease Digestive system Excretory system Medical sciences Membranes Pharmacology. Drug treatments Rodents Therapy |
title | rHuKGF ameliorates symptoms in DSS and CD4+CD45RBHi T cell transfer mouse models of inflammatory bowel disease |
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