rHuKGF ameliorates symptoms in DSS and CD4+CD45RBHi T cell transfer mouse models of inflammatory bowel disease

rHuKGF ameliorates symptoms in DSS and CD4+CD45RBHi T cell transfer mouse models of inflammatory bowel disease

There is an acute need for effetive therapy for inflammatory bowel disease IBD particularly at the level of repair of the damaged epithelium. We evaluated the efficacy of recombinant human keratinocyte growth factor (rHuKGF) in both the dextran sodium sulfate (DSS) and the CD4+CD45RBHi T cell transf...

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Veröffentlicht in:American journal of physiology: Gastrointestinal and liver physiology 2002-04, Vol.45 (4), p.G690-G701
Hauptverfasser: BYRNE, Fergus R, FARRELL, Catherine L, ZIEGLER, Thomas R, SENALDI, Giorgio, ARANDA, Richard, REX, Karen L, SCULLY, Sheila, BROWN, Heather L, FLORES, Silvia A, GU, Li H, DANILENKO, Dimitry M, LACEY, David L
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Bowel disease
Digestive system
Excretory system
Medical sciences
Membranes
Pharmacology. Drug treatments
Rodents
Therapy
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Zusammenfassung:There is an acute need for effetive therapy for inflammatory bowel disease IBD particularly at the level of repair of the damaged epithelium. We evaluated the efficacy of recombinant human keratinocyte growth factor (rHuKGF) in both the dextran sodium sulfate (DSS) and the CD4+CD45RBHi T cell transfer models of IBD.
ISSN:0193-1857
1522-1547