Gastroprotective and vasodilatory effects of epidermal growth factor : the role of sensory afferent neurons

Epidermal growth factor (EGF) has been shown to exert gastric hyperemic and gastroprotective effects via capsaicin-sensitive afferent neurons, including the relase of calcitonin gene-related peptide (CGRP). We examined the protective and vasodilatory effects of EGF on the gastric mucosa and its inte...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2001-05, Vol.43 (5), p.G897-G903
Hauptverfasser:	MATSUMOTO, Yoji, KANAMOTO, Kohki, KAWAKUBO, Keishi, AOMI, Hitoshi, MATSUMOTO, Takayuki, IBAYASHI, Setsuro, FUJISHIMA, Masatoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Digestive system Medical sciences Neurons Peptides Pharmacology. Drug treatments Sensory perception
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Beschreibung
Zusammenfassung:	Epidermal growth factor (EGF) has been shown to exert gastric hyperemic and gastroprotective effects via capsaicin-sensitive afferent neurons, including the relase of calcitonin gene-related peptide (CGRP). We examined the protective and vasodilatory effects of EGF on the gastric mucosa and its interaction with sensory nerves, CGRP, and nitric oxide (NO) in anesthetized rats.
ISSN:	0193-1857 1522-1547