COX inhibition excites enteric nerves that affect motility, alkaline secretion, and permeability in rat duodenum

COX inhibition excites enteric nerves that affect motility, alkaline secretion, and permeability in rat duodenum

In anesthetized rats, the cyclooxygenase (COX) inhibitor indomethacin induces duodenal motility, increases duodenal mucosal alkaline secretion (DMAS), and evokes a transient increase in duodenal paracellular permeability (DPP). To examine whether enteric nerves influence these responses, the duodenu...

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Veröffentlicht in:American journal of physiology: Gastrointestinal and liver physiology 2001-11, Vol.44 (5), p.G1169-G1178
Hauptverfasser: NYLANDER, Olof, HALLGREN, Anneli, SABABI, Manaf
Format: Artikel
Sprache:eng
Schlagworte:
Anesthetics. Neuromuscular blocking agents
Biochemistry
Biological and medical sciences
Digestive system
Fundamental and applied biological sciences. Psychology
Intestine. Mesentery
Medical sciences
Neurons
Neuropharmacology
Pharmacology. Drug treatments
Rodents
Vertebrates: digestive system
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Zusammenfassung:In anesthetized rats, the cyclooxygenase (COX) inhibitor indomethacin induces duodenal motility, increases duodenal mucosal alkaline secretion (DMAS), and evokes a transient increase in duodenal paracellular permeability (DPP). To examine whether enteric nerves influence these responses, the duodenum was perfused with lidocaine.
ISSN:0193-1857
1522-1547