Failure of Alzheimer's A[Beta](1-40) Amyloid Nanofibrils under Compressive Loading

Failure of Alzheimer's A[Beta](1-40) Amyloid Nanofibrils under Compressive Loading

Amyloids are associated with severe degenerative diseases and show exceptional mechanical properties, in particular great stiffness. Amyloid fibrils, forming protein nanotube structures, are elongated fibers with a diameter of [asymptotically =]8 nm with a characteristic dense hydrogen-bond (H-bond)...

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Veröffentlicht in:JOM (1989) 2010-04, Vol.62 (4), p.64
Hauptverfasser: Paparcone, Raffaella, Buehler, Markus J
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer's disease
Deformation
Disease
Experimental methods
Mechanical properties
Nanomaterials
Net losses
NMR
Nuclear magnetic resonance
Pathogens
Proteins
Research methodology
Simulation
Solvents
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Zusammenfassung:Amyloids are associated with severe degenerative diseases and show exceptional mechanical properties, in particular great stiffness. Amyloid fibrils, forming protein nanotube structures, are elongated fibers with a diameter of [asymptotically =]8 nm with a characteristic dense hydrogen-bond (H-bond) patterning in the form of beta-sheets (β-sheets).
ISSN:1047-4838