Phenprocoumon-Induced Hepatitis Delaying Precise Diagnosis in a Thrombophilic Patient With Activated Protein C Resistance Due to Factor V R506Q Mutation

Wuillemin et al report the case of a thrombophilic patient with activated protein C resistance who was repeatedly put on oral anticoagulants for recurrent venous thrombosis and pulmonary embolism and who twice developed a hepatitis-like clinical presentation following exposure to phenprocoumon. Prot...

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Veröffentlicht in:	The American journal of medicine 1997-11, Vol.103 (5), p.437-439
Hauptverfasser:	Wuillemin, Walter A, Zenhäusern, Reinhard, Bernhard, Marie-Claire, Lämmle, Bernhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anticoagulants - adverse effects Biological and medical sciences Cardiovascular disease Case studies Chemical and Drug Induced Liver Injury - complications Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - etiology Diagnosis, Differential Drug therapy Drug toxicity and drugs side effects treatment Factor V - genetics Female Hepatitis Humans Medical sciences Mutation Pharmacology. Drug treatments Phenprocoumon - adverse effects Protein C - metabolism Side effects Thrombophilia - complications Thrombophilia - diagnosis Thrombophilia - genetics Thrombophilia - metabolism Toxicity: digestive system
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Zusammenfassung:	Wuillemin et al report the case of a thrombophilic patient with activated protein C resistance who was repeatedly put on oral anticoagulants for recurrent venous thrombosis and pulmonary embolism and who twice developed a hepatitis-like clinical presentation following exposure to phenprocoumon. Protein C plasma levels may be decreased for several months after liver damage.
ISSN:	0002-9343 1555-7162
DOI:	10.1016/S0002-9343(97)00174-5