Differential effects of interleukin-1 receptor antagonist in cytokine- and endotoxin-treated rats

The metabolic effects of interleukin (IL)-1 and tumor necrosis factor (TNF) were examined in rats during a fed state provided by continuous intravenous feeding for 20 hours. Results showed that during feeding IL-1 is responsible for the increase in glucose flux and plasma insulin, the development of...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 1995-02, Vol.31 (2), p.E255-E261
Hauptverfasser:	PEI RA LING, ISTFAN, N. W, COLON, E, BISTRIAN, B. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and medical sciences Hormones. Endocrine system Medical sciences Metabolism Pharmacology. Drug treatments Proteins Rodents
Online-Zugang:	Volltext
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Zusammenfassung:	The metabolic effects of interleukin (IL)-1 and tumor necrosis factor (TNF) were examined in rats during a fed state provided by continuous intravenous feeding for 20 hours. Results showed that during feeding IL-1 is responsible for the increase in glucose flux and plasma insulin, the development of insulin resistance, and plasma zinc depression during condition mimicking sepsis and injury.
ISSN:	0193-1849 1522-1555