Differential effects of corticosteroids on rat peripheral blood T-lymphocyte mitogenesis in vivo and in vitro

The effects of corticosteroids were studied on the concanavalin A-induced mitogenesis of peripheral blood T-lymphocytes obtained from intact and adrenalectomized (ADX) Wistar rats. It is concluded that high corticosteroid concentrations in vivo and in vitro occurred only in the presence of antigluco...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 1993-12, Vol.28 (6), p.E825-E830
Hauptverfasser:	WIEGERS, G. J, CROISET, G, REUL, J. M. H. M, HOLSBOER, F, DE KLOET, E. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Immunity (Disease) Immunobiology Lymphatic system Medical research Modulation of the immune response (stimulation, suppression) Rodents Steroids
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Zusammenfassung:	The effects of corticosteroids were studied on the concanavalin A-induced mitogenesis of peripheral blood T-lymphocytes obtained from intact and adrenalectomized (ADX) Wistar rats. It is concluded that high corticosteroid concentrations in vivo and in vitro occurred only in the presence of antiglucocorticoids.
ISSN:	0193-1849 1522-1555