A compartmental model of 3-methylhistidine metabolism in humans

Urinary 3-methylhistidine (3MH) excretion has been suggested as a noninvasive in vivo marker of muscle protein breakdown, but such analysis needs quantitative collection of urine and offers few details about the metabolism of 3MH. It is suggested that data from a single bolus tracer and serial blood...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 1995-07, Vol.32 (1), p.E193-E198
Hauptverfasser:	RATHMACHER, J. A, FLAKOLL, P. J, NISSEN, S. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and medical sciences Investigative techniques, diagnostic techniques (general aspects) Kinetics Medical sciences Metabolism Osteoarticular system. Muscles Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Urology
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Beschreibung
Zusammenfassung:	Urinary 3-methylhistidine (3MH) excretion has been suggested as a noninvasive in vivo marker of muscle protein breakdown, but such analysis needs quantitative collection of urine and offers few details about the metabolism of 3MH. It is suggested that data from a single bolus tracer and serial blood samples over 72 hours can be described by a kinetic model that defines 3MH metabolism in humans.
ISSN:	0193-1849 1522-1555