Long-term effects on pancreatic function of feeding a HC formula to rats during the preweaning period

Prancreatic changes associated with hyperinsulinemia and an insulin secretroy response to an oral glucose load in a new rat model of obesity were investigated in an experiment in which rats were reared on either a high-carbohydrate or high-fat formula. Results show that consumption of a high-carbohydrate formula during the suckling period influences pancreatic islet morphology resulting in hyperinsulinemia, which leads to the development of obesity.