Melatonin secretion occurs at a constant rate in both young and older men and women

The magnitude and duration of melatonin (MLT) secretion were measured over a period of 25 h with pharmacokinetic studies employing administration of D7 MLT at midday and at midnight in two separate studies and two groups of subjects, 12 young and 11 older men and women. Plasma levels of endogenous M...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2001, Vol.43 (1), p.E11-E22
Hauptverfasser:	FOURTILLAN, J. B, BRISSON, A. M, FOURTILLAN, M, INGRAND, I, DECOURT, J. P, GIRAULT, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Endocrine system Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Kinetics Pharmacology Studies Vertebrates: endocrinology
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Zusammenfassung:	The magnitude and duration of melatonin (MLT) secretion were measured over a period of 25 h with pharmacokinetic studies employing administration of D7 MLT at midday and at midnight in two separate studies and two groups of subjects, 12 young and 11 older men and women. Plasma levels of endogenous MLT and D7 MLT were quantified separately by use of a specific and sensitive method (gas chromatography-mass spectrometry) previously developed in our laboratory, enabling us to measure endogenous and exogenous MLT levels downt o 0.5 pg/ml in plasma.
ISSN:	0193-1849 1522-1555