Do sex steroids regulate glutamine synthesis with age?

Do sex steroids regulate glutamine synthesis with age?

Glutamine synthetase, a key enzyme in the production of glutamine, is known to be induced by glucocorticoids and preserved in skeletal muscle during aging, but the effect of other steroids, such as sex steroids (progesterone, estradiol), is unknown in vivo. The aim of this study was to determine whe...

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Veröffentlicht in:American journal of physiology: endocrinology and metabolism 2002, Vol.45 (1), p.E215-E221
Hauptverfasser: VERDIER, Lionel, BOIRIE, Yves, VAN DRIEESCHE, Sebastien, MIGNON, Michelle, BEGUE, Rene-Jean, MEYNIAL-DENIS, Dominique
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Animal reproduction
Biological and medical sciences
Heart
Muscular system
Steroids
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Zusammenfassung:Glutamine synthetase, a key enzyme in the production of glutamine, is known to be induced by glucocorticoids and preserved in skeletal muscle during aging, but the effect of other steroids, such as sex steroids (progesterone, estradiol), is unknown in vivo. The aim of this study was to determine whether progesterone or estradiol plays a role in the regulation of glutamine synthetase (GS) with aging.
ISSN:0193-1849
1522-1555