Mechanism of gluconeogenesis inhibition in rat hepatocytes isolated after in vivo hypoxia

Gluconeogenesis was studied in hepatocytes isolated from fasted rats submitted to 24 hours of hypoxic exposure or to room air. In vivo hypoxic exposure inhibits gluconeogenesis at the phosphoenolpyruvate carboxykinase (PEPCK) level by decreasing PEPCK gene transcription.

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Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 1995-05, Vol.31 (5), p.E965-E973
Hauptverfasser:	PISON, C. M, CHAUVIN, C, FONTAINE, E, CATELLONI, F, KERIEL, C, PARAMELLE, B, LEVERVE, X. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carbohydrates Cellular biology Fundamental and applied biological sciences. Psychology Genetics Liver Metabolism Metabolisms and neurohumoral controls Rodents Vertebrates: anatomy and physiology, studies on body, several organs or systems
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Gluconeogenesis was studied in hepatocytes isolated from fasted rats submitted to 24 hours of hypoxic exposure or to room air. In vivo hypoxic exposure inhibits gluconeogenesis at the phosphoenolpyruvate carboxykinase (PEPCK) level by decreasing PEPCK gene transcription.
ISSN:	0193-1849 1522-1555